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The Perez Lab Transgenic Mouse Project Our transgenic mouse has a systemically overexpressed, constitutively active a1b adrenergic receptor. It displays phenotypes similar to Epilepsy, Parkinson's Plus and/or Multiple System Atrophy (Shy-Drager) in its locomotion dysfunction and neurodegeneration. It may prove a useful model for neurodegenerative diseases and their potential treatments. |
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