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  • The Laboratory of
  • Dianne M. Perez
  • Department of Molecular Cardiology
  • Lerner Research Institute
  • Cleveland Clinic Foundation
  • Cleveland OH 44195

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  • My laboratory is interested in three major areas of research:

    • 1) To determine how ligands bind in the
    • .....receptor.
    • 2) To determine the mechanisms of
    • ....activation.
    • 3) To determine the physiological role(s)
    • ....and possible pathology that is
    • particular subtypes of
    • ...a1-adrenergic receptors.
    Lab Publications
    • Time-lapse imagery of a DNA
    • ....purification step using gel
    • ....electrophoresis.
    • When the purple dye reaches the bottom
    • ....of the gel, the gel is placed on top
    • ....of a UV .light source, which makes the ....bands of DNA fluoresce an orange ....color.


    The Perez Lab Transgenic Mouse Project

    Our transgenic mouse has a systemically overexpressed, constitutively active a1b adrenergic receptor. It displays phenotypes similar to Epilepsy, Parkinson's Plus and/or Multiple System Atrophy (Shy-Drager) in its locomotion dysfunction and neurodegeneration.

    It may prove a useful model for neurodegenerative diseases and their potential treatments.